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Ichthyosis hystrix : ウィキペディア英語版 | Ichthyosis hystrix
Ichthyosis hystrix is a group of rare skin disorders in the ichthyosis family of skin disorders characterized by massive hyperkeratosis with an appearance like spiny scales.〔(''Ichthyosis hystrix'' ), DermIS〕 This term is also used to refer to a type of epidermal nevi with extensive bilateral distribution.〔 ==Ichthyosis hystrix, Curth-Macklin type==
The symptoms of Ichthyosis hystrix Curth-Macklin are similar to epidermolytic hyperkeratosis (NPS-2 type) but there is no blistering and the hyperkeratosis is verrucous or spine-like. The hyperkeratosis is brown-grey in colour and is most obvious on the arms and legs. It is an autosomal dominant condition and can be caused by errors to the KRT1 gene.〔(【引用サイトリンク】work=Rare Disease Registry )〕 It is named after Helen Ollendorff Curth (1899-1982), a German-Jewish dermatologist, and Madge Thurlow Macklin (1893–1962), an American medical geneticist, and is one of the first syndromes named after two women.
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